La maladie de Parkinson au Canada (serveur d'exploration)

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The axonal arborization of single nigrostriatal neurons in rats

Identifieur interne : 003794 ( Main/Exploration ); précédent : 003793; suivant : 003795

The axonal arborization of single nigrostriatal neurons in rats

Auteurs : J. Gauthier [Canada] ; M. Parent [Canada] ; M. Levesque [Canada] ; A. Parent [Canada]

Source :

RBID : Pascal:99-0432072

Descripteurs français

English descriptors

Abstract

Neurons of the substantia nigra pars compacta (SNc) were iontophoretically injected with biotin dextran and their anterogradely labeled axons individually reconstructed from serial sagittal sections. Most nigrostriatal axons travelled directly to the striatum, where they branched abundantly. Other axons arborized profusely in various extrastriatal structures, including the globus pallidus, the entopeduncular and subthalamic nuclei, and branched only sparsely in the striatum. This heterogeneous organization of the nigrostriatal projection allows single SNc neurons to influence differently striatal neurons and to act directly upon extrastriatal components of the basal ganglia via a highly patterned set of collaterals.


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Le document en format XML

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